Palmitoylethanolamide (PEA) is an endogenously produced lipid produced in microglia and mast cells. PEA is a type of fatty acid ethanolamine that helps maintain neurological health. It may also help relieve occasional muscle pain due to overuse.
It is found in higher amounts in areas of the brain involved in nociception, and clinical trials have demonstrated broad effectiveness for the relief of occasional muscle pain due to overuse both alone and in combination with standard treatment. In addition, PEA may help support healthy endothelial function, normal intraocular pressure, and a healthy mood.